CANCER BIOLOGY & EPIGENETICS GROUP
CBEG was established in 2008 and integrates predoctoral and postdoctoral researchers, with diverse academic backgrounds, including Biologists, Biochemists, Pathological, Cytological, and Thanatological Anatomy graduates, and Medical Doctors of several specialties, including Pathologists, Urologists, Gynecologists, Radiologists, Hemato-Oncologists, and Medical Oncologists.
In the context of Precision Oncology, we are developing several patient-centered pre-clinical and fundamental research projects addressing tumor biology, pathology, epigenetics, epitranscriptomics, tumor metabolism, and immunology topics.
SCIENTIFIC COORDINATOR
Carmen Jerónimo, PhD
ORCID ID/ Ciência ID: 0000-0003-4186-5345/ CE16-29CB-EDD1
Assistant Researcher
IPO Porto Research Director
TL2 – Cancer Coordinator / CI-IPOP@RISE-Associate Laboratory
Scientific Coordinator, Biobank – Department of Pathology
Guest Full Professor at ICBAS-School of Medicine & Biomedical Sciences, Univ. Porto
President, ASPIC-Portuguese Association for Cancer Research
Chair, Translational Research Section/ESUR of the European Association of Urology
E-mail: carmenjeronimo@ipoporto.min-saude.pt/cljeronimo@icbas.up.pt
TEAM
Senior Researchers
Rui Henrique, MD, PhD
ORCID ID/ Ciência ID: 0000-0003-3171-4666/ 641F-FE09-15E6
Senior Researcher
Senior Consultant Pathologist and Director, Department of Pathology
Guest Full Professor at ICBAS-School of Medicine & Biomedical Sciences, Univ. Porto E-mail: henrique@ipoporto.min-saude.pt/ rmhenrique@icbas.up.pt
Margareta P. Correia, PhD
ORCID ID/ Ciência ID: 0000-0003-4378-0820/ CB11-3261-9D4F
Assistant Researcher
Team Leader of the research topic: Onco-Immuno-Epigenetics
Lecturer at ICBAS-UP under the IPO Porto & ICBAS-UP Protocol
E-mail: margareta.correia@ipoporto.min-saude.pt
Junior Researchers
Carla Bartosch, MD, PhD
ORCID ID/ Ciência ID: 0000-0003-0646-7667/ 881F-BDAC-46FE
Consultant Pathologist, Department of Pathology
Team Leader of the research topic: Gynecological Tumors
Lecturer in Pathology at ICBAS-UP under the IPO Porto & ICBAS-UP Protocol
E-mail: carla.bartosch@ipoporto.min-saude.pt
João Lobo, MD, PhD
Consultant in Pathology, Department of Pathology
ORCID ID/ Ciência ID: 0000-0001-6829-1391/ 8A14-8221-1CBF
Team Leader of the research topic: Testicular Tumors
Guest Assistant Professor at ICBAS-School of Medicine & Biomedical Sciences, UP
E-mail: jpedro.lobo@ipoporto.min-saude.pt
María Gallardo Gómez, PhD
Postdoctoral Researcher – Instituto de Investigación Sanitaria Galicia Sur (IISGS), Vigo, Spain
ORCID ID/ Ciência ID: 0000-0002-4856-9322 / 3B13-67B3-72E2
E-mail: maria.gomez@ipoporto.min-saude.pt
Sara Monteiro-Reis, PhD
ORCID ID/ Ciência ID: 0000-0002-2193-2793/ 3014-05F4-935F
Project Manager – EUnetCCC JA
Lecturer at ICBAS-UP under the IPO Porto & ICBAS-UP Protocol
E-mail: sara.reis@ipoporto.min-saude.pt
Vera Miranda-Gonçalves, PhD
ORCID ID/ Ciência ID: 0000-0002-4231-5532/ 8E1B-B722-284F
Lab Manager – Lab3
Lecturer at ICBAS-UP under the IPO Porto & ICBAS-UP Protocol
E-mail: vera.miranda.goncalves@ipoporto.min-saude.pt
Guest Researchers
Diana Montezuma, PhD
ORCID ID/ Ciência ID: 0000-0001-9551-4589 / 8614-D72D-4861
E-mail: diana.m.felizardo@ipoporto.min-saude.pt
Liliana Raimundo, PhD
ORCID ID/ Ciência ID: 0000-0001-9003-2601 / B21B-623F-AA05
E-mail: liliana.raimundo@ipoporto.min-saude.pt
Óscar Rapado González, PhD
Postdoctoral Researcher – Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain
ORCID ID/ Ciência ID: 0000-0001-8419-7004 / C019-EAAE-BBB8
E-mail: oscar.gonzalez@ipoporto.min-saude.pt
Sofia Salta, PhD
ORCID ID/ Ciência ID: 0000-0002-6707-1263 / 6119-2B18-6A26;
E-mail: sofia.salta@ipoporto.min-saude.pt
Agnese Orsatti, MD
Resident in Pathology – University of Bologna, Italy
ORCID ID/ Ciência ID: 0009-0005-8560-1925 / 3614-3DC8-B863
E-mail: agnese.orsatti@studio.unibo.it
PhD Students
With External Funding
Supervising
Amal Magdy Mohamed, MSc (in collaboration with KU Leuven, Belgium; PROSTAMET – H2020 MSCA-GA No. 101120283)
ORCID ID/ Ciência ID: 0009-0004-0514-9725 / BB1D-00E9-DB8C
E-mail: aml.mohamed@ipoporto.min-saude.pt
Ana Teixeira-Marques, MSc (in collaboration with i3S/ Centro de investigación Hospital Universitario 12 de Octubre, Espanha; FCT2023.01232.BD);
ORCID ID/Ciência ID: 0000-0003-1396-3466/ 601F-802B-922D;
E-mail: ana.t.marques@ipoporto.min-saude.pt
Catarina Lourenço, MSc (in collaboration with i3S; FCT2021.06731.BD);
ORCID ID/ Ciência ID: 0000-0003-0644-0202/ 9A1E-2DE0-A004;
E-mail: i37296@ipoporto.min-saude.pt
Filipa Domingues dos Reis, MSc (in collaboration with Leiden University Medical Center, The Netherlands; FCT UI/BD/154816/2023);
ORCID ID/ Ciência ID: 0000-0001-9897-5612/ C014-A6CE-0341;
E-mail: filipa.reis@ipoporto.min-saude.pt
Filipa Moreira Silva, MSc (in collaboration with Bern Univ Hospital, Bern, Switzerland; FCT 2023.00300.BD);
ORCID ID/ Ciência ID: 0000-0002-7272-7300/ 7019-D06D-3E3F;
E-mail: filipa.m.silva@ipoporto.min-saude.pt
Íris da Rocha Carriço, MSc (in collaboration with MFRRP; FCT UI/BD/154815/2023);
ORCID ID/ Ciência ID: 0000-0002-4977-8273/ 3617-1D5C-EE2D;
E-mail: iris.carrico@ipoporto.min-saude.pt
João Martins da Gama, MD
ORCID ID/ Ciência ID: 0000-0001-5274-4114 / 9E1A-51E8-0B2C
E-mail: joaomartinsgama@gmail.com
João Moura e Silva, MD
ORCID ID/ Ciência ID: 0000-0001-8579-6543 / 241A-85E2-1BF3
E-mail: jricardo.moura.silva@gmail.com
José Pedro Sequeira, MSc (in collaboration with Health Research Institute of Santiago de Compostela-IDIS, Spain; FCT2022.11060.BD);
ORCID ID/ Ciência ID: 0000-0002-4687-3347/ FE1E-E1CF-6983;
E-mail: jose.leite.sequeira@ipoporto.min-saude.pt
Marta Avelar, MSc (in collaboration with i3S; FCT2025.02786.BD);
ORCID ID/ Ciência ID: 0000-0002-1961-6513 / 331A-DB95-F399
E-mail: marta.avelar@ipoporto.min-saude.pt
Nuno Tiago Tavares, MSc (in collaboration with the University of California, San Diego, USA; FCT2022.09566.BD);
ORCID ID/ Ciência ID: 0000-0001-8426-1838/ 2718-0ED1-9F74;
E-mail: i38161@ipoporto.min-saude.pt
Vera Constâncio, MSc (in collaboration with Champalimaud Foundation/Beatson Institute, Glasgow, Scotland; LCF/BQ/DR20/11790013);
ORCID ID/ Ciência ID: 0000-0002-3151-0367/ 3116-280A-8462;
E-mail: vera.salvado.constancio@ipoporto.min-saude.pt
Co-Supervising
Mariana Carvalho, MSc (INEGI; FCT2022.09480.BD);
ORCID ID/ Ciência ID: 0000-0001-8620-9718/ 7713-CE2C-47D2;
E-mail: mariana.carvalho@ipoporto.min-saude.pt
Maria Miguel Castro, MSc (i3S; FCT2020.07439.BD);
ORCID ID/ Ciência ID: 0000-0001-5016-2567/ F41B-905E-E21F;
E-mail: mcastro@i3s.up.pt
Sanjana Vig, MSc (REQUIMTE;H2020 MSCA-GA ID: 861138);
ORCID ID/ Ciência ID: 0000-0001-7939-6500/ 911E-5E8D-888C;
E-mail: sanjana@fmd.up.pt
IPO PORTO STAFF
Ana Fernandes Rodrigues, MD;
ORCID ID/ Ciência ID: 0000-0003-2955-055 / 371A-3A6B-696F;
E-mail: ana.fernandes.rodrigues@ipoporto.min-saude.pt
Carlos Ochoa Leite, MD;
ORCID ID/ Ciência ID: 0000-0003-0489-9677 / 7B14-471C-19A5;
E-mail: carlos.ochoa.leite@ipoporto.min-saude.pt
Carina Carvalho-Maia, MSc;
ORCID ID/ Ciência ID: 0000-0002-7011-8341 / B116-C629-89AC;
E-mail: i13035@ipoporto.min-saude.pt
Isaac Braga, MD (in collaboration with CHUP);
ORCID ID/ Ciência ID: 0000-0001-9265-4324 / A31B-745C-57EA;
E-mail: isaac.braga@ipoporto.min-saude.pt
João André Carvalho, MD;
ORCID ID/ Ciência ID: 0000-0001-8564-2050 / B318-599E-9623;
E-mail: joao.m.carvalho@ipoporto.min-saude.pt
Lígia Gonçalves, MD;
ORCID ID/ Ciência ID: 0000-0002-5864-8526 / 0D10-301A-79F6;
E-mail: ligiagoncalves@ipoporto.min-saude.pt
Mónica Pires, MD (CINTESIS@RISE);
ORCID ID/ Ciência ID: 0000-0003-2238-5135/ 451E-BFE8-40BF;
E-mail: monica.pires@ipoporto.min-saude.pt
Rui Freitas, MD;
ORCID ID/ Ciência ID: 0000-0002-4448-6458/ F01F-89CB-26E6;
E-mail: antoniofreitas@ipoporto.min-saude.pt
Rui Silva-Santos, MSc; Pathology Technician
ORCID ID/ Ciência ID: 0000-0002-6392-1785/ 0E14-7605-B96D;
E-mail: rui.silva.santos@ipoporto.min-saude.pt
Sérgio Chacim, MD;
ORCID ID/ Ciência ID: 0000-0002-6316-8789/ A317-C226-0F98; E-mail: sergio.chacim@ipoporto.min-saude.pt
Sofia Paulino, MSc; Pathology Technician
ORCID ID/ Ciência ID: 0000-0003-1244-4066/ C31D-B4FF-D098
E-mail: sofia.paulino@ipoporto.min-saude.pt
Research Assistants/Technicians
Fernanda Fernandes-Pontes, MSc
ORCID ID/ Ciência ID: 0009-0007-3931-0443 / 1C19-894E-FD30
E-mail: fernanda.pontes@ipoporto.min-saude.pt
Mariana Lima-Costa, MSc
ORCID ID/ Ciência ID: 0009-0001-3257-3693 / 261D-7564-4CD4
E-mail: mariana.l.costa@ipoporto.min-saude.pt
Mariana Silva-Ferreira, MSc (PTDC/EME-APL/1342/2020);
ORCID ID/ Ciência ID: 0000-0002-5896-051X/ 521F-556D-5E8E;
E-mail: mariana.ferreira@ipoporto.min-saude.pt
MSc Students
Anatasiia Ponosova; Integrated Master in Medicine, ICBAS-UP
Bárbara Amorim Fernandes, BSc; Master in Oncology, ICBAS-UP
Beatriz Parente Gonçalves, BSc, Master in Bioengineering, FEUP/ICBAS-UP
Berta Camille, BSc, Master in Biomedical Sciences-Molecular Mechanisms of Diseases, University of Antwerp, Belgium
Diana Almeida-Pereira, BSc; Master in Oncology, ICBAS-UP
Emilie Van Oproy, BSc, Master in Biomedical Sciences-Molecular Mechanisms of Diseases, University of Antwerp, Belgium
Francesca Roma, BSc; Master in Molecular Medicine & Medical Biotechnology, University of Bari, Italy
Gabriela Assunção, BSc; Master in Oncology, ICBAS-UP
Gonçalo Silva-Rodrigues, BSc; Master in Oncology, ICBAS-UP
Jéssica Cordeiro, BSc; Master in Oncology, ICBAS-UP
Jéssica Sousa, BSc; Master in Molecular and Cellular Biology, FCUP
Lara Silva Cunha; Integrated Master in Medicine, ICBAS-UP
Margarida Morais, BSc; Master in Oncology, ICBAS-UP
Maria Inês Reis, BSc; Master in Oncology, ICBAS-UP
Mariana Melo e Costa, BSc; Master in Oncology, ICBAS-UP
Marta Rodrigues, BSc; Master in Oncology, ICBAS-UP
Other collaborators
Alexandra Lapa, MSc; Resident in Pathology
Ana Isabel Varelas, MSc; Attending Pathologist
Ana Luísa Cunha, MD; Consultant Pathologist
Ana Teresa Martins, MSc; Pathology Technician
Andreia Coutada, MSc; Resident in Pathology
Ângelo Rodrigues, MD; Consultant Pathologist
Candy Paiva, BSc; Pathology Technician
Carla Renata Dias, MD; Consultant Pathologist
Carolina Duque, MSc; Resident in Pathology
Davide Gigliano, MD; Attending Pathologist
Fernanda Silva, BSc; Pathology Technician
Isa Carneiro, MSc; Pathology Technician
Jorge Torres-Ferreira, MSc; Pathology Technician
Júlia Azevedo, MD; Resident in Pathology
Maria Alzamora; MD; Resident in Pathology
Nuno Coimbra, MD; Consultant Pathologist
Paula Dias, BSc; Pathology Technician
Paula Lopes, BSc; Pathology Technician
Paula Monteiro, MD; Consultant Pathologist
Renata Vieira, BSc; Pathology Technician
Rita Guimarães, MSc; Pathology Technician
Sérgio Lopes, PhD; Cell Therapy Clinical Scientist
Verónica Ferreira, BSc; Pathology Technician
Aims
The core aim of our group is to portray in depth epigenetic/ epitranscriptomic mechanisms involved in carcinogenesis, which might be used as clinical tools for early detection, diagnosis, prognostication, and therapy prediction. The investigation of the mechanism and role of epigenetic-modulating drugs (epi-drugs) is another major goal. Moreover, owing to the relevance that Immuno-oncology has demonstrated in recent years, we are also exploring the epigenetic modulation of biomolecules involved in immune responses, aiming at the improvement of immunotherapeutic strategies.
PROJECTS WITH EXTERNAL FUNDING (click to more information)
PROJECTS WITH INTERNAL FUNDING (click to more information)
PATENTS
(2012) Methods and biomarkers for detection of bladder cancer; US 20130210011/ EP 2630261 A1/ WO 2012052844 A1 (in collaboration Oslo University Hospital)
(2023) Prostate cancer recurrence risk calculator; Provisional Patent PT 20242005764083
NATIONAL COLLABORATIONS
Celso Reis | IPATIMUP, i3S
Fátima Baltazar & Bruno Costa | ICVS/3Bs, U. Minho
Goreti Sales | U. Coimbra
Joana Paredes | IPATIMUP, i3S
João F Mano | CICECO – U. Aveiro
João P Ferreira | FEUP
Lucília Saraiva | LAQV/REQUIMTE
Luisa Helguero | IBiMED, U. Aveiro
Margarida Fardilha | IBiMED, U. Aveiro
Maria José Oliveira | INEB, i3S
Meriem Lamghari | INEB, i3S
Nuno Lunet, ISPUP
Paula Guedes | REQUIMTE-FF
Raquel Almeida | IPATIMUP, i3S
Sara Ricardo | 1H-TOXRUN, IUCS
INTERNATIONAL COLLABORATIONS
Aditya Bagrodia | University of California San Diego, USA
Alejandro Sifrim & Johan Swinnem | KU Leuven, Belgium
Ángel Díaz-Lagares | Epigenomics Unit, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago de Compostela-IDIS, Spain
Catherine Muller | IPBS-CNRS, Université de Toulouse, France
Elena Martens-Uzunova | Erasmus Medical Center, Rotterdam, The Netherlands
Florence Le Calvez-Kelm | IARC, Lyon, France
Gabri van der Pluijm | Leiden University Medical Center, The Netherlands
Giuseppina Carbone | Belinzona, Switzerland
Guro Lind | Radium Hospital, Oslo, Norway
Hector Peinado CNIO, Madrid, Spain
Hing Leung | CRUK-Glasgow, UK
Isabelle Bernard-Pierrot | Institut Curie, Paris, France
Jesús M. Paramio & Marta Dueñas | Biomedical Research Institute I+12, University Hospital “12 de Octubre”, Madrid, Spain
Laura Muinelo-Romay & María Mercedes Suárez-Cunqueiro | Liquid Biopsy Analysis Unit, Translational Medical Oncology (Oncomet), Health Research Institute of Santiago de Compostela-IDIS, Spain
Lucia Altucci | Università degli studi della Campania “Luigi Vanvitelli”, Naples, Italy
Manel Esteller | Josep Carreras Leukaemia Research Institute, Barcelona, Spain
Marianna Kruithof-de Julio | Bern Univ Hospital, Switzerland
Mónica Martínez-Fernández, CIMUS, University of Santiago de Compostela, Spain
Paola Arimondo | Institute Pasteur, Paris, France
Sandra Blanco | Centro de Investigación del Cáncer, Salamanca, Spain
Wilbert Zwart | NKI, Amsterdam, The Netherlands
Valérie Taly | Université Paris Descartes, Paris, France
*The information described in the group is the sole responsibility of the respective coordinator.
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