GRUPO DE ONCOLOGIA CLÍNICA
The Clinical Oncology Research Group (GOC) was created in 2021.
Its main mission is to create a group of scientifically robust and capable elements among different health professionals.
GOC projects seek to answer clinical questions resulting from real needs, by analyzing real-life data, to continuously improve the quality of treatment offered to patients.
Although recent, the GOC team has been expanding, integrating elements that have invested in their academic progression and elements that have completed clinical internships at internationally renowned oncology centers, such as the MD Anderson Cancer Center and Gustave Roussy.
The multidisciplinary nature of its elements is a differentiating characteristic and promotes stimulating, fruitful and advantageous discussions for scientific research. Its members are committed to the group’s mission.
SCIENTIFIC COORDINATOR
Ana Espírito Santo, MD, PhD
ORCID ID/ Ciência ID: 0000-0002-4840-590X/ DA1B-35B9-E2D4
Consultant Clinical Hematologist
Email: ana.esanto@ipoporto.min-saude.pt
TEAM
Senior Researchers
Cláudia Vieira, MD, PhD
ORCID ID/ Ciência ID: 0000-0001-5396-9753/ 641E-265C-9730
Consultant Medical Oncologist
Email: claudia.vieira@ipoporto.min-saude.pt
Magda Andrea Silva Oliveira, PhD
ORCID ID/ Ciência ID: 0000-0002-0653-341X/ E614-C685-6817
Psychologist
Email: magda.oliveira@ipoporto.min-saude.pt
Maria Deolinda Pereira, MD, PhD
ORCID ID/ Ciência ID: 0000-0003-2367-1299/ 991B-E677-158E
Senior Consultant Medical Oncologist
Email: dpereira@ipoporto.min-saude.pt
Mavilde Rodrigues Arantes da Silva Longarito, MD, PhD
ORCID ID/ Ciência ID: 0000-0002-0297-2247/ 6E17-7D72-53E7
Consultant Neuroradiologist
Email: i11815@ipoporto.min-saude.pt
Miguel Henriques Abreu, MD, PhD
ORCID ID/ Ciência ID: 0000-0003-3940-0688/ F61D-1E69-3148
Consultant Medical Oncologist
Email: antonio.m.abreu@ipoporto.min-saude.pt
Joaquim Castro Silva, MD, PhD
ORCID ID/ Ciência ID: 0000-0002-3934-9950/ B418-68AE-3A6A
Consultant Otorrinolaringologist
Email: joaquim.castro@ipoporto.min-saude.pt
Jorge Serafim Sobrado Marinho, MD, PhD
ORCID ID/ Ciência ID: 0000-0003-1222-627X/ 311C-6EF7-EB13
Consultant Otorrinolaringologist
Email: jmarinho@ipoporto.min-saude.pt
Guest Researchers
Rita Ribeiro Silva, PhD
ORCID ID/ Ciência ID:
Attending Clinical Hematologist @
Email: rita.rbsilva@gmail.com
PhD Students
Daniela Rocha-Santos, MSc (with ETPG)
ORCID ID/ Ciência ID: 0000-0003-1081-5142/ 4617-DBEA-8AE6
Email: daniela.r.santos@ipoporto.min-saude.pt
José Manuel Ferrer Martinez, BSN, MSc; Specialist nurse
ORCID ID/ Ciência ID: 0000-0002-7909-7938/ DF1B-A0A1-2302
Email: jmmartinez@ipoporto.min-saude.pt
Pedro Miguel dos Reis Cruz, MD, MSc Resident in Medical Oncology (with ETPG)
ORCID ID/ Ciência ID: 0000-0001-8813-0632/ 0610-621F-B88A
Email: pedro.reis.cruz@ipoporto.min-saude.pt
Valéria Delgado Tavares, MSc (with MOVPG)
ORCID ID/ Ciência ID: 0000-0003-3680-7757/ B715-3863-A1DA
Email: valeria.tavares@ipoporto.min-saude.pt
Other collaborators
Alina Rosinha, MD, MSc, Attending Medical Oncologist
Ana Alexandra Ferreira, MD, BSc, Consultant Medical Oncologist
Ana Filipa Carneiro, MD, BSc Attending Medical Oncologist
Ana Isabel Vaz Ferreira MD, MSc, Resident in Medical Oncology
Ana Maria Meireles MD, MSc,Resident in Clinical Hematology
Ana Raquel Teixeira MD, MSc, Resident in Medical Oncology
Ana Rita Lopes MD, MSc; Attending Medical Oncologist
Ana Sofia Jardim Patrão MD, MSc; Attending Medical Oncologist
Andreia Guimarães da Cruz, MD, MSc, Attending Medical Oncologist
Cátia Faustino, MD, BSc, Consultant Medical Oncologist
Cláudia Melissa de Paiva Agostinho MD, MSc, Resident in Medical Oncology
Cláudia Sílvia da Rocha Moreira, MD, BSc, Attending Clinical Hematologist
Dânia Sofia Marques Santos, MD, MSc Consultant Medical Oncologist
Dulcineia José Nunes de Alves Pereira, MD, BSc Attending Hemato-oncologist
Hugo André do Nascimento Ferreira, MD, MSc; Attending Nefrologist
Inês Baptista Freitas, MD, MSc, Resident in Medical Oncology
Joana Savva Bordalo e Sa, MD, MSc Consultant Medical Oncologist
João Pedro Gouveia da Fonseca, MD, MSc; Resident in Medical Oncology
José Brito da Silva, MD, MSc; Resident in Medical Oncology
Maria Cândida Silva, MD, MSc; Attending General and Family Medicine
Maria Gabriela Martins, MD, BSc; Consultant Medical Oncologist
Maria Isabel Vilas-Boas, MD, MSc; Attending Medical Oncologist
Maria Joaquina Maurício, MD, MSc; Senior Consultant Medical Oncologist
Maria Cassiano Neves, MD, BSc; Consultant Medical Oncologist
Marta Soares, MD, BSc, Senior Consultant Medical Oncologist
Marta Isabel Ribeiro Ferreira, MD, MSc; Consultant Medical Oncologist
Michael Sapateiro Luís, MD, MSc; Consultant Medical Oncologist
Nuno Duarte Gonçalves, MD, BSc; Senior Consult Clinical Patologist
Olga Dulce Sousa de Meneses, MD, MSc; Resident in Medical Oncology
Paula Cristina da Silva Ferreira, MD, BSc; Consultant Medical Oncologist
Rita Amorim e Costa, MD, MSc; Resident in Medical Oncology
Rute Fernandes, MD, MSc; Resident in Medical Oncology
Sara Cristina Neves de Carvalho, MD, MSc; Resident in Medical Oncology
Sara Marina Carneiro Pinto Coelho, MD, MSc Attending Medical Oncologist
Susana Sousa Almeida, MD, MSc; Senior Consultant Psychiatrist
Vítor Costa, MD, BSc Attending Pediatrician
Aims
The main objective of the GOC is to establish bridges between clinical practice and translational research, in order to allow patients access to more efficient and innovative treatments.
The GOC encourages clinical studies of research initiative and promotes collaborative efforts both internally, with other groups at the Research Center, but also externally through partnerships with national and international organizations.
A cornerstone of the GOC is encouraging the continuous training of health professionals, with a focus on improving the quality of care provided to cancer patients.
PROJECTS WITH EXTERNAL FUNDING
Epidemiological characterization of the population of patients with chronic myeloid leukemia treated at the Porto IPO – Portuguese Association Against Leukemia, Portuguese Society of Hematology and Novartis; 15 000 € (2023); Dr. Ana Meireles (PI)
The introduction of tyrosine kinase inhibitors (TKI) was revolutionary in the treatment of chronic myeloid leukemia (CML). The focus changed from delaying the progression of the disease to more advanced stages, to obtaining a survival similar to the general population, achieving a profound molecular response and discontinuing therapy while maintaining remission. Furthermore, it is increasingly important to consider the effects of TKIs on patients’ quality of life and patient-reported outcomes in the therapeutic approach. There are several studies on responses and adverse effects in patients with CML. However, the characterization of these patients in Portugal is not yet known. This project’s main objective is to describe the population of patients with CML treated at IPOP and, in parallel, to describe adverse effects of TKIs documented in these patients and which patients are candidates for TKI suspension and whether there was a need to resume TKIs.
FAROL – Implementation of a financing model based on the measurement of clinical and non-clinical outcomes and integrated disease management in lung cancer at IPO Porto; (2018-2023); Dr. Marta Soares (PI)
The FAROL pilot project, focusing on Health Results and Integrated Disease Management, consists of developing a financing model focused on measuring results with incentives associated with quality.
CHIP-AML22 – Improved diagnostics and survival for all children with Acute Myeloid Leukemia treated within the NOPHO-DB- SHIP consortium; a cross-European collaboration;193 481,68€ (2022-2025); Dr. Vítor Costa (PI @ IPO Porto)
The CHIP-AML22 project seeks to implement new diagnostic techniques for Acute Myeloid Leukemia (AML) to improve the treatment of patients with these diseases. This consortium seeks to:
– Perform the genetic profile of AML cells to better stratify the risk group of patients.
-WGS and RNA seq analysis to incorporate and improve patient treatment;
– The implementation and evaluation of the response to treatment of both methods during and after treatment, across the consortium.
HENKO NET – Innovation and Digital Technologies for Social and Health Palliative Care at home; 157 886,96€ (2024-2026); Dr. Maria Paula Silva (PI @ IPO Porto)
In several European countries such as Spain, France and Portugal, only a portion of people in need of palliative care (PC) actually receive it.
However, PC are essential in controlling symptoms, providing relief, and respecting people’s dignity and as such are an ethical obligation. The significant number of patients needing PC would like to receive them at home, which constitutes an increase in well-being.
HENKO means in Japanese a profound and transformative change. Thus, this project seeks to establish a community of knowledge to strengthen CP systems and lead to organizational change. HENKO NET aims to promote innovation and the adoption of innovative digital technologies so that continuous care is possible at patients’ homes and in rural areas.
The partners in this project will seek a joint strategy to promote innovative advanced training and exchange of best practices in new care models and the adoption of effective digital technologies among healthcare professionals.
The most innovative result expected from this project will be the development of the HENKO platform based on artificial intelligence for the early detection of the need for CP and the anticipation of unwanted events (medical or social). This is expected to significantly improve the organization of care with more effective monitoring at home and a reduction in hospitalizations.
Patients, families and professionals will be actively involved in this development and will be piloted with 100 patients to determine its effectiveness and efficiency. Cooperation between beneficiaries from the three countries (SP, FR and PT) is essential, since innovation in this area is very scarce, so expanding the work scenario at a transnational level will provide sufficient knowledge to develop solutions.
Selected publications (up to five)
- Almeida, S. N., Elliott, R., Silva, E. R., & Sales, C. M. D. (2019). Fear of cancer recurrence: A qualitative systematic review and meta-synthesis of patients’ experiences. Clinical psychology review, 68, 13–24. https://doi.org/10.1016/j.cpr.2018.12.001
- Moreira, I., Ferreira, M., Garcia, S., Novais, P., Gama, J., Ferro, B., Leite-Silva, P., Frutuoso, C., Pires, M., Barbosa, A., Pinto, C., Teixeira, M. R., Pereira, D., & Bartosch, C. (2023). Practical lessons learned from real-world implementation of the molecular classification for endometrial carcinoma. Gynecologic oncology, 176, 53–61. https://doi.org/10.1016/j.ygyno.2023.07.005
- Mazza, M., Piperis, M., Aasaithambi, S., Chauhan, J., Sagkriotis, A., & Vieira, C. (2022). Social Media Listening to Understand the Lived Experience of Individuals in Europe With Metastatic Breast Cancer: A Systematic Search and Content Analysis Study. Frontiers in oncology, 12, 863641. https://doi.org/10.3389/fonc.2022.863641
- Henriques-Abreu, M., & Serrano, C. (2021). Avapritinib in unresectable or metastatic gastrointestinal stromal tumor with PDGFRA exon 18 mutation: safety and efficacy. Expert review of anticancer therapy, 21(10), 1081–1088. https://doi.org/10.1080/14737140.2021.1963235